Toll like receptors: an overview

Toll-like receptors: an overview from invertebrates to vertebrates

Toll-like receptors (TLRs) are membrane glycoproteins consisting of an ectodomain, encompassing tandem LRRs (leucine-rich repeats), a membrane spanning segment and a globular cytoplasmic Toll/Interleukin-1 Receptor (TIR) domain. They detect microbes on the basis of conserved Pathogen-Associated Molecular Patterns (PAMPs). TLRs share molecular architecture and common ancestors with arthropod Tol...

I-23: Reproduction and Toll Like Receptors(TLRs

Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...

The Role of Toll-Like Receptors in Breast Cancer

Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...

The Role of Toll Like Receptors in Pregnancy

P-172: Intracellular Toll Like Receptors Expression in Endometriosis

Background: Endometriosis is a complex disease that profoundly affects the quality of life in many women. This disease affects roughly one in ten women of reproductive age. Endometriosis induces a variable amount of inflammatory reaction in pelvic environment. An active immune system needs to recognize these inflammatory agents. Rapid innate immune system defenses against infections involve the...